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TUhjnbcbe - 2021/1/12 3:38:00

一般而言,该方法主要用于芳基酮或二芳基酮的还原。

Et3SiH-BF3还原示例1

Adry,-mL,three-necked,round-bottomedflaskisequippedwithamagneticstirringbar,agas-inlettube,apressure-equalizingdroppingfunnel,andaDewarcondensercooledwithice-waterandfittedwithadryingtubecontaininganhydrouscalciumsulfate(Drierite).Asolutionof20.9g(0.mol)oftriethylsilanein80mLofdichloromethaneisplacedintheflask.Thesolutionisstirredrapidlyandcooledinanicebathwhileborontrifluoridegasisintroducedbelowthesurfaceoftheliquidatamoderaterate.Thefirstappearanceofwhitefumesattheexitofthedryingtubeindicatesthatthesolutionissaturatedandtheapparatusisfilledwithborontrifluoride.Theflowofborontrifluorideisadjustedtoalevelsufficienttomaintainaslightemissionofwhitefumesfromthedryingtube,andasolutionof10.0g(0.mol)ofm-nitroacetophenonein30mLofdichloromethaneisaddeddropwiseduring10min.Stirringandcoolingarecontinuedfor30min,afterwhichtheflowofborontrifluoridegasisstoppedandthecoolingbathisremoved.Themixtureisstirredatroomtemperaturefor20min,cooledagainwiththeicebath,andhydrolyzedbyadding20mLofaqueoussaturatedsodiumchloride.Theupperorganiclayerisdecantedfromthesalts,whicharethendissolvedin50mLofwater.Theaqueoussolutionisextractedwithtwo25mLportionsofpentane,whichare

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